PathScan® Phospho-Tau (Ser214) Sandwich ELISA Kit #44177
- ELISA
Supporting Data
| REACTIVITY | H M R |
Application Key:
- ELISA-ELISA
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Description
*Antibodies in this kit are custom formulations specific to kit.
Protocol
Specificity / Sensitivity
Species Reactivity:
Background
Numerous kinases including PKA, CDK5, GSK3β and SGK1 have been shown to phosphorylate tau at Ser214. In addition, investigators have shown that tau is phosphorylated at Ser214 in Alzheimer's disease and dementia with Lewy bodies (4-9). Investigators have shown that tau phosphorylation at Ser214 detaches tau protein from microtubules, protecting it against aggregation into Alzheimer paired helical filaments (10).
- Johnson, G.V. and Stoothoff, W.H. (2004) J Cell Sci 117, 5721-9.
- Hanger, D.P. et al. (1998) J Neurochem 71, 2465-76.
- Bramblett, G.T. et al. (1993) Neuron 10, 1089-99.
- Illenberger, S. et al. (1998) Mol Biol Cell 9, 1495-512.
- Götz, J. et al. (2001) Science 293, 1491-5.
- Yang, Y.C. et al. (2006) Mol Cell Biol 26, 8357-70.
- Liu, F. et al. (2006) FEBS Lett 580, 6269-74.
- Zhu, B. et al. (2010) Am J Physiol Lung Cell Mol Physiol 299, L493-501.
- Duka, V. et al. (2013) PLoS One 8, e75025.
- Schneider, A. et al. (1999) Biochemistry 38, 3549-58.
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