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4/3/2025, 10:58:56 PM UTC
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XML generation date: 2025-03-25 13:27:08.407
Product last modified at: 2025-04-01T08:00:11.949Z
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PDP - Template Name: Blocking Peptide
PDP - Template ID: *******6db2f4c

β-Catenin Blocking Peptide #1002

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Pricing & Additional Information

To learn more about our Blocking Peptides, including pricing or custom products, please submit a product inquiry request.

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Important Ordering Details

Custom Ordering Details: This product is assembled upon order. Please allow two-four weeks for your product to be processed.

Product Information

Storage

Supplied in 20 mM potassium phosphate (pH 7.0), 50 mM NaCl, 0.1 mM EDTA, 1 mg/ml BSA and 5% glycerol. 1% DMSO. Store at –20°C.

Product Description

This peptide is used to block β-Catenin (6B3) Rabbit mAb #9582 and β-Catenin Antibody (Carboxy-terminal Antigen) #9587 reactivity in dot blot protocols.

Quality Control

The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry. The peptide blocks β-Catenin (6B3) Rabbit mAb #9582 and β-Catenin Antibody (Carboxy-terminal Antigen) #9587 by dot blot.

Background

β-catenin is a key downstream effector in the Wnt signaling pathway (1). It is implicated in two major biological processes in vertebrates: early embryonic development (2) and tumorigenesis (3). CK1 phosphorylates β-catenin at Ser45. This phosphorylation event primes β-catenin for subsequent phosphorylation by GSK-3β (4-6). GSK-3β destabilizes β-catenin by phosphorylating it at Ser33, Ser37, and Thr41 (7). Mutations at these sites result in the stabilization of β-catenin protein levels and have been found in many tumor cell lines (8).

Pathways

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