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Render Timestamp: 2025-01-02T12:29:03.899Z
Commit: 286c369131ceeedcf44c821941824d8d7e009e57
XML generation date: 2024-04-05 20:22:15.836
Product last modified at: 2025-01-01T09:06:52.273Z
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PDP - Template Name: Blocking Peptide
PDP - Template ID: *******6db2f4c

Cleaved Caspase-3 (Asp175) Blocking Peptide #1050

Pricing & Additional Information

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Important Ordering Details

Custom Ordering Details: This product is assembled upon order. Please allow two-four weeks for your product to be processed.

    Product Information

    Product Usage Information

    Use as a blocking reagent to evaluate the specificity of antibody reactivity in dot blot protocols.

    Storage

    Supplied in 20 mM potassium phosphate (pH 7.0), 50 mM NaCl, 0.1 mM EDTA, 1 mg/ml BSA, 5% glycerol and 1% DMSO. Store at –20°C.

    Product Description

    This peptide is used to block Cleaved Caspase-3 (Asp175) (D3E9) Rabbit mAb #9579 reactivity.

    Quality Control

    The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry. The peptide reacts with Cleaved Caspase-3 (Asp175) (D3E9) Rabbit mAb #9579 by dot blot.

    Background

    Caspase-3 (CPP-32, Apopain, Yama, SCA-1) is a critical executioner of apoptosis, as it is either partially or totally responsible for the proteolytic cleavage of many key proteins, such as the nuclear enzyme poly (ADP-ribose) polymerase (PARP) (1). Activation of caspase-3 requires proteolytic processing of its inactive zymogen into activated p17 and p12 fragments. Cleavage of caspase-3 requires the aspartic acid residue at the P1 position (2).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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