Render Target: STATIC
Render Timestamp: 2024-12-13T11:36:39.096Z
Commit: 611277b6de3cd1bb065350b6ef8d63df412b7185
XML generation date: 2024-09-20 06:14:19.453
Product last modified at: 2024-05-30T07:12:12.030Z
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PDP - Template Name: Blocking Peptide
PDP - Template ID: *******6db2f4c
  1. Products /
  2. Experimental Controls /
  3. Phospho-S6 Ribosomal Protein (Ser235/236) Blocking Peptide

Phospho-S6 Ribosomal Protein (Ser235/236) Blocking Peptide #1220

Pricing & Additional Information

To learn more about our Blocking Peptides, including pricing or custom products, please submit a product inquiry request.

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Important Ordering Details

Custom Ordering Details: This product is assembled upon order. Please allow two-four weeks for your product to be processed.

    Product Information

    Product Usage Information

    Use as a blocking reagent to evaluate the specificity of antibody reactivity in dot blot protocols.

    Storage

    Supplied in 20 mM potassium phosphate (pH 7.0), 50 mM NaCl, 0.1 mM EDTA, 1 mg/ml BSA, 5% glycerol and 1% DMSO. Store at –20°C.

    Product Description

    This peptide is used to block Phospho-S6 Ribosomal Protein (Ser235/236) Antibody #2211 reactivity.

    Quality Control

    The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry. The peptide reacts with Phospho-S6 Ribosomal Protein (Ser235/236) Antibody #2211 signal in dot blot.

    Background

    One way that growth factors and mitogens effectively promote sustained cell growth and proliferation is by upregulating mRNA translation (1,2). Growth factors and mitogens induce the activation of p70 S6 kinase and the subsequent phosphorylation of S6 ribosomal protein. Phosphorylation of S6 ribosomal protein correlates with an increase in translation of mRNA transcripts that contain an oligopyrimidine tract in their 5' untranslated regions (2). These particular mRNA transcripts (5'TOP) encode proteins involved in cell cycle progression, as well as ribosomal proteins and elongation factors necessary for translation (2,3). Important S6 ribosomal protein phosphorylation sites include several residues (Ser235, Ser236, Ser240, and Ser244) located within a small, carboxy-terminal region of S6 protein (4,5).~No product specific background information is currently available for this product.

    Database Links

    UniProt ID: P62753


    Entrez-Gene Id: 6194


    Limited Uses

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    For Research Use Only. Not For Use In Diagnostic Procedures.
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