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Commit: f2d32940205a64f990b886d724ccee2c9935daff
XML generation date: 2024-09-20 06:21:26.168
Product last modified at: 2024-12-17T19:01:50.988Z
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PDP - Template Name: IHC Control Slides
PDP - Template ID: *******ff9c92b
  1. Products /
  2. Experimental Controls /
  3. SignalSlide® Cleaved Caspase-3 (Asp175) IHC Controls

SignalSlide® Cleaved Caspase-3 (Asp175) IHC Controls #8104

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Custom Ordering Details: Sections are cut freshly upon ordering. Please allow up to three business days for your product to be processed.

    Product Information

    Product Description

    Each control slide contains formalin fixed, paraffin-embedded Jurkat cells, both untreated and treated with etoposide, that serve as a control for cleaved caspase-3 (Asp 175) immunostaining. Western blot analysis was performed on extracts derived from the same cells to verify the efficacy of the etoposide treatment.

    To be used with antibodies: 9664, 9661, 9662, 2035, 9541.

    Background

    Caspase-3 (CPP-32, Apopain, Yama, SCA-1) is a critical executioner of apoptosis, as it is either partially or totally responsible for the proteolytic cleavage of many key proteins, such as the nuclear enzyme poly (ADP-ribose) polymerase (PARP) (1). Activation of caspase-3 requires proteolytic processing of its inactive zymogen into activated p17 and p12 fragments. Cleavage of caspase-3 requires the aspartic acid residue at the P1 position (2).

    Database Links

    UniProt ID: P42574


    Entrez-Gene Id: 836


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    For Research Use Only. Not For Use In Diagnostic Procedures.
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