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TCF1/TCF7 Blocking Peptide

TCF1/TCF7 Blocking Peptide #1007

Name: TCF1/TCF7 Blocking Peptide
Price: 404.00 USD
Availability: InStock

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Product Information

Storage

Supplied in 20 mM potassium phosphate (pH 7.0), 50 mM NaCl, 0.1 mM EDTA, 1 mg/ml BSA and 5% glycerol. 1% DMSO. Store at –20°C.

Product Description

This peptide is used to block TCF1/TCF7 (C63D9) Rabbit mAb #2203 reactivity in dot blot protocols.

Quality Control

The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry. The peptide blocks TCF1/TCF7 (C63D9) Rabbit mAb #2203 by dot blot.

Background

LEF1 and TCF are members of the high mobility group (HMG) DNA-binding protein family of transcription factors that consists of the following: Lymphoid Enhancer Factor 1 (LEF1), T Cell Factor 1 (TCF1/TCF7), TCF3/TCF7L1, and TCF4/TCF7L2 (1). LEF1 and TCF1/TCF7 were originally identified as important factors that regulate early lymphoid development (2) and act downstream in Wnt signaling. LEF1 and TCF bind to Wnt response elements to provide docking sites for β-catenin, which translocates to the nucleus to promote the transcription of target genes upon activation of Wnt signaling (3). LEF1 and TCF are dynamically expressed during development and aberrant activation of the Wnt signaling pathway is involved in many types of cancers, including colon cancer (4,5).

Database Links

UniProt ID: P36402

Entrez-Gene Id: 6932

Limited Uses

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For Research Use Only. Not For Use In Diagnostic Procedures.

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