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Render Timestamp: 2024-11-22T11:25:10.951Z
Commit: 5c4accf06eb7154018ba3f54329c7590f97f534a
XML generation date: 2024-09-18 13:54:16.489
Product last modified at: 2024-10-01T13:45:08.090Z
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PDP - Template Name: InTraSeq Conjugate
PDP - Template ID: *******e148868
  1. Products /
  2. InTraSeq™ Kits & Reagents /
  3. CD4 (RPA-T4) Mouse mAb (InTraSeq™ 3' Conjugate 3029)

CD4 (RPA-T4) Mouse mAb (InTraSeq™ 3' Conjugate 3029) #87589

Filter:
  • SCA

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa)
    Source/Isotype Mouse IgG1
    Application Key:
    • SCA-Single Cell Analysis 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Storage

    Supplied in PBS (pH 7.2), 2 mM EDTA, 0.05% Triton X-100, 2 mg/mL BSA, and 50% glycerol. Store at -20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    CD4 (RPA-T4) Mouse mAb (InTraSeq™ 3' Conjugate 3029) recognizes endogenous levels of total CD4 protein. This antibody detects an epitope within the extracellular domain.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with PHA-stimulated human peripheral blood mononuclear cells.

    Background

    Cluster of Differentiation 4 (CD4) is a glycoprotein composed of an amino-terminal extracellular domain (four domains: D1-D4 with Ig-like structures), a transmembrane part, and a short cytoplasmic tail. CD4 is expressed on the surface of T helper cells, regulatory T cells, monocytes, macrophages, and dendritic cells, and plays an important role in the development and activation of T cells. On T cells, CD4 is the co-receptor for the T cell receptor (TCR), and these two distinct structures recognize the Antigen–Major Histocompatibility Complex (MHC). Specifically, the D1 domain of CD4 interacts with the β2-domain of the MHC class II molecule. CD4 ensures specificity of the TCR–antigen interaction, prolongs the contact between the T cell and the antigen presenting cell, and recruits the tyrosine kinase Lck, which is essential for T cell activation (1).

    Database Links

    UniProt ID: P01730


    Entrez-Gene Id: 920


    Limited Uses

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    For Research Use Only. Not For Use In Diagnostic Procedures.
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