Ikaros (D6N9Y) Rabbit mAb (InTraSeq™ 3' Conjugate 3026) #42531
- SCA
Supporting Data
| REACTIVITY | H M |
| SENSITIVITY | Endogenous |
| MW (kDa) | |
| Source/Isotype | Rabbit IgG |
Application Key:
- SCA-Single Cell Analysis
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
Product Information
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Ikaros (IKZF1, LYF1) is the prototypical Ikaros family zinc-finger transcription factor and is expressed abundantly in lymphoid cells. Genetic studies in mice demonstrate that Ikaros is a tumor suppressor that is important for the normal development of B, T, natural killer, and dendritic cells (3,4). Additional studies show that imbalanced expression of different Ikaros isoforms, as well as mutations in the corresponding IKAROS gene, can be associated with a number of hematologic malignancies in humans (2,5,6).
- Perdomo, J. et al. (2000) J Biol Chem 275, 38347-54.
- Rebollo, A. and Schmitt, C. (2003) Immunol Cell Biol 81, 171-5.
- Georgopoulos, K. et al. (1997) Annu Rev Immunol 15, 155-76.
- Nichogiannopoulou, A. et al. (1998) Semin Immunol 10, 119-25.
- Tonnelle, C. et al. (2002) Leuk Lymphoma 43, 29-35.
- Martinelli, G. et al. (2009) J Clin Oncol 27, 5202-7.
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