Render Target: STATIC
Render Timestamp: 2024-11-22T11:42:22.561Z
Commit: 5c4accf06eb7154018ba3f54329c7590f97f534a
XML generation date: 2024-04-05 20:48:15.101
Product last modified at: 2024-06-07T14:00:08.247Z
1% for the planet logo
PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464

ABAT Antibody #64430

Filter:
  • WB

    Supporting Data

    REACTIVITY H M R
    SENSITIVITY Endogenous
    MW (kDa) 56
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    ABAT Antibody recognizes endogenous levels of total ABAT protein.

    Species Reactivity:

    Human, Mouse, Rat

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly43 of human ABAT protein. Antibodies are purified by protein A and peptide affinity chromatography.

    Background

    4-aminobutyrate aminotransferase (ABAT) is an enzyme localized within the mitochondrial matrix that acts to catabolize γ-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the central nervous system. ABAT deficiency leads to elevated GABA levels and is associated with a variety of neurological afflictions, including mood and cognitive disorders, psychomotor retardation, and seizures (1,2). Genetic variants of ABAT have also been linked to Alzheimer’s disease (3). In addition to the neurological implications, dysregulation of GABA as a consequence of ABAT deficiency has been linked to the pathogenesis of breast and liver cancers (4-6). Collectively, these studies suggest that ABAT may be a therapeutic target for both neurological disorders and some forms of cancer.
    For Research Use Only. Not For Use In Diagnostic Procedures.
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