Render Target: STATIC
Render Timestamp: 2024-12-20T11:48:27.112Z
Commit: f2d32940205a64f990b886d724ccee2c9935daff
XML generation date: 2024-08-01 15:28:27.833
Product last modified at: 2024-11-21T14:45:07.772Z
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PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464

ACP/NDUFAB1 Antibody #61560

Filter:
  • WB

    Supporting Data

    REACTIVITY H Mk
    SENSITIVITY Endogenous
    MW (kDa) 9
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 
    • Mk-Monkey 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    ACP/NDUFAB1 Antibody recognizes endogenous levels of total ACP/NDUFAB1 protein.

    Species Reactivity:

    Human, Monkey

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human ACP/NDUFAB1 protein. Antibodies are purified by protein A and peptide affinity chromatography.

    Background

    Mitochondrial acyl carrier protein (ACP) is an essential component in fatty acid biosynthesis in mitochondria. It is also known as NADH-ubiquinone oxidoreductase subunit AB1 (NDUFAB1), a complex I subunit in the electron transport chain (ETC). NDUFAB1 regulates energy and reactive oxygen species (ROS) metabolism in mitochondria by coordinating the assembly of ETC complexes I, II, and III, and supercomplexes (1). Studies show that overexpression of this protein protects the heart from ischemia-reperfusion injury in mice as well as protects mice from insulin resistance and obesity (1,2). In addition, NDUFAB1 mRNA levels are upregulated in pancreatic ductal adenocarcinoma compared with normal pancreatic ductal tissues (3).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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