Render Target: STATIC
Render Timestamp: 2025-01-28T10:42:42.353Z
Commit: 8d9f38232df81570bbc23eaa560b31cb39dd8776
XML generation date: 2024-08-01 15:24:19.742
Product last modified at: 2024-05-30T07:15:43.686Z
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PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464

ACVR1 Antibody #4398

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  • WB

Inquiry Info. # 4398

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    Supporting Data

    REACTIVITY H M Mk
    SENSITIVITY Endogenous
    MW (kDa) 57
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • Mk-Monkey 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    ACVR1 Antibody detects endogenous levels of total ACVR1 protein. The antibody also cross-reacts with 35 kDa and 95 kDa bands of unknown origin.

    Species Reactivity:

    Human, Mouse, Monkey

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human ACVR1 protein. Antibodies were purified by protein A and peptide affinity chromatography.

    Background

    The activin A receptor type 1 (ACVR1) is a membrane associated serine/threonine kinase receptor that binds activin A and related TGF-β superfamily growth factors, including bone morphogenetic protein 2 (BMP2) and BMP4, 6 and 7 (1-3). Functional activin receptors are composed of a pair of type I and type II activin receptor proteins. Following ligand binding, ACVR1 is phosphorylated by its type II binding partner, which allows recruitment and activation of receptor regulated SMAD (R-Smad) proteins (4). Phosphorylation of R-Smad proteins results in their translocation to the nucleus where R-Smads stimulate transcription of target genes (5). Mutations in the corresponding ACVR1 gene are associated with the genetic developmental disorders hereditary hemorrhagic telangiectasia and fibrodysplasia ossificans progressive (6,7).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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