ADAMTS1 (D5G4Z) Rabbit mAb #12897
- WB
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 110 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
ADAMTS1 has been shown to possess potent anti-angiogenic activity in vitro (2) and is reportedly dysregulated in a number of cancer subtypes (7). Functional in vivo studies in an ADAMTS1 knockout mouse model suggested that ADAMTS1 promotes metastatic invasion of breast carcinoma cells (8). These studies showed a reduced tumor burden in ADAMTS1 knockout mice, which was linked to increased cytotoxic immune cell invasion and reduced tumor cell survival (8).
- Tang, B.L. and Hong, W. (1999) FEBS Lett 445, 223-5.
- Apte, S.S. (2009) J Biol Chem 284, 31493-7.
- Vázquez, F. et al. (1999) J Biol Chem 274, 23349-57.
- Luque, A. et al. (2003) J Biol Chem 278, 23656-65.
- Lu, X. et al. (2009) Genes Dev 23, 1882-94.
- Kuno, K. et al. (1999) J Biol Chem 274, 18821-6.
- Mochizuki, S. and Okada, Y. (2007) Cancer Sci 98, 621-8.
- Ricciardelli, C. et al. (2011) Am J Pathol 179, 3075-85.
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