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AIFM2/FSP1 Antibody

AIFM2/FSP1 Antibody #24972

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Supporting Data

REACTIVITY	H
SENSITIVITY	Endogenous
MW (kDa)	41
SOURCE	Rabbit

Application Key:

WB-Western Blotting

Species Cross-Reactivity Key:

H-Human

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

AIFM2/FSP1 Antibody recognizes endogenous levels of total AIFM2/FSP1 protein.

Species Reactivity:

Human

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human AIFM2/FSP1 protein. Antibodies are purified by peptide affinity chromatography.

Background

Apoptosis-inducing factor mitochondria-associated 2 (AIFM2), also known as AIF-homologous mitochondrion-associated inducer of death (AMID) or p53-responsive gene 3 (PRG3), is a homolog of apoptosis-inducing factor (AIF) (1,2). Research studies show that it inhibits ferroptosis, a form of cell death caused by iron-dependent lipid peroxidation. Therefore, this protein was named as ferroptosis suppressor protein 1 (FSP1). FSP1 is a coenzyme Q₁₀(CoQ) oxidoreductase and generates the reduced form of (CoQ), which traps lipid peroxides, leading to the suppression of ferroptosis. Furthermore, inhibition of ferroptosis by FSP1 was shown to be independent of GPX4, another negative regulator of ferroptosis (3,4).

Database Links

UniProt ID: Q9BRQ8

Entrez-Gene Id: 84883

Limited Uses

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For Research Use Only. Not For Use In Diagnostic Procedures.

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