Render Target: STATIC
Render Timestamp: 2024-11-22T10:37:56.646Z
Commit: 5c4accf06eb7154018ba3f54329c7590f97f534a
XML generation date: 2024-09-20 06:15:33.093
Product last modified at: 2024-11-07T16:30:09.057Z
1% for the planet logo
PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464

ALDH2 Antibody #18818

Filter:
  • WB

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 56
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    ALDH2 Antibody recognizes endogenous levels of total ALDH2 protein.

    Species Reactivity:

    Human

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val348 of human ALDH2 protein. Antibodies are purified by protein A and peptide affinity chromatography.

    Background

    Aldehyde dehydrogenase 2 (ALDH2) is a member of the aldehyde dehydrogenase superfamily (1). The enzymes in this family catalyze the oxidation of a variety of aldehydes, leading to their detoxification (1, 2). ALDH2 activation correlates with decreased ischemic heart injury, suggesting an essential role of ALDH2 in cardiac protection from ischemic injury (3). In addition, ALDH2 is the primary enzyme for aldehyde oxidation in hematopoietic stem cells (4). ALDH2 is required for protecting these cells from DNA damage caused by acetaldehyde and has a critical function to counteract genotoxicity (4, 5).
    For Research Use Only. Not For Use In Diagnostic Procedures.
    Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
    All other trademarks are the property of their respective owners. Visit our Trademark Information page.