Alix (E4T7U) Rabbit mAb #18269
- WB
Supporting Data
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 90-100 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Alix has also been shown to be involved in the biogenesis of exosomes, small secreted vesicles that contribute to cell signaling (7, 8). In addition, Alix interacts with Atg12-Atg3 to promote autophagy and endosomal fusion (9)
- Mattei, S. et al. (2006) Eur. J. Cell Biol. 85, 925-936.
- Odorizzi, G. (2006) J. Cell Sci. 119, 3025-3032.
- Vito, P. et al. (1999) J. Biol. Chem. 274, 1533-1540.
- Missotten, M. et al. (1999) Cell Death Differ. 6, 124-129.
- Katoh, K. et al. (2003) J. Biol. Chem. 278, 39104-39113.
- Sadoul, R. (2006) Biol. Cell 98, 69-77.
- Baietti, M.F. et al. (2012) Nat Cell Biol 14, 677-85.
- Chatellard-Causse, C. et al. (2002) J Biol Chem 277, 29108-15.
- Murrow, L. et al. (2015) Nat Cell Biol 17, 300-10.
Limited Uses
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