AMACR (2A10) Mouse mAb #3207
- WB
Supporting Data
| REACTIVITY | H M |
| SENSITIVITY | Endogenous |
| MW (kDa) | 42 |
| Source/Isotype | Mouse IgG2b |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
AMACR (2A10) Mouse mAb detects endogenous levels of total AMACR protein.
Species Reactivity:
Human, Mouse
Source / Purification
Monoclonal antibody is produced by immunizing animals with a purified truncated recombinant human AMACR-His fusion protein.
Background
α-Methylacyl-CoA racemase (AMACR), an enzyme localized in peroxisomes and mitochondria, is involved in the β-oxidation of branched-chain fatty acids and fatty acid derivatives (1). AMACR has been reported to be a biomarker for prostate cancer (2-4). AMACR expression is also related to other types of cancers, such as hepatocellular carcinoma (1), noninvasive bladder cancer (5), colorectal cancer (6), and gastric adenocarcinoma (7).
- Li, W. et al. (2008) J Exp Clin Cancer Res 27, 2.
- Rubin, M.A. et al. (2002) JAMA 287, 1662-70.
- Jiang, Z. et al. (2002) Am J Surg Pathol 26, 1169-74.
- Jiang, Z. et al. (2001) Am J Surg Pathol 25, 1397-404.
- Gunia, S. et al. (2008) Virchows Arch 453, 165-70.
- Marx, A. et al. (2008) Virchows Arch 453, 243-248.
- Truong, C.D. et al. (2008) Int J Clin Exp Pathol 1, 518-523.
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