ANT1/SLC25A4 Antibody #69569
- WB
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 28 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
ANT1/SLC25A4 Antibody recognizes endogenous levels of total ANT1/SLC25A4 protein. This antibody does not cross-react with ANT2/SLC25A5 protein.
Species Reactivity:
Human
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala150 of human ANT1/SLC25A4 protein. Antibodies are purified by peptide affinity chromatography.
Background
Adenine nucleotide translocators (ANTs) are a family of mitochondrial proteins that exchange ATP and ADP across the mitochondrial inner membrane. ANT1, also known as solute carrier family 25 member 4 (SLC25A4), is the isoform predominantly expressed in heart, muscle, and brain (1,2). Homozygous loss-of-function mutations in ANT1/SLC25A4 causes cardiomyopathy (2,3). In addition, ANT1/SLC25A4 is shown to be required for mitophagy (3). Furthermore, research studies show that ANT1/SLC25A4 facilitates mitochondrial permeability transition induced by bile acids and, therefore, pyroptosis (4). ANT1/SLC25A4 may mediate the release of ATP from mitochondria to the cytoplasm in this process, which is critical for pyroptosome assembly (4).
Limited Uses
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