ApoE2 (E6U9I) Rabbit mAb #62273
- WB
To Purchase # 62273
| Cat. # | Size | Qty. | Price |
|---|---|---|---|
| 62273T | 20 µl | $153 | |
| 62273S | 100 µl | $339 |
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Recombinant protein |
| MW (kDa) | 35 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- Related Products
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Simple Western™ | 1:10 - 1:50 |
Storage
For a carrier free (BSA and azide free) version of this product see product #75018.
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Human ApoE has three isoforms: ApoE2, ApoE3, and ApoE4. These three isoforms differ in the combination of cysteine and arginine residues located at positions 130 and 176. The ApoE2 isoform contains cysteine at both locations. ApoE4 has been identified as a genetic risk factor for Alzheimer’s disease (AD), where ApoE2 is neuroprotective, reducing risk of AD by nearly 50%. The neuroprotective mechanism of ApoE2 remains under investigation, but studies suggest that this may be due to its overall protein abundance in non-AD human cortex and its unique lipid binding profile compared to ApoE3 and ApoE4, which may increase overall β-amyloid clearance (3).
Limited Uses
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