APP (Aducanumab Biosimilar) Human mAb #59870

Supporting Data

REACTIVITY	H
SENSITIVITY	Endogenous
MW (kDa)
Source/Isotype	Human IgG kappa

Species Cross-Reactivity Key:

H-Human

Product Information

Product Description

APP (Aducanumab Biosimilar) Human mAb is a biosimilar antibody for Aducanumab. Aducanumab is a human monoclonal antibody that targets aggregated forms of amyloid beta (Aβ) derived from amyloid precursor protein (APP).

Endotoxin

<0.1 EU/μg of antibody

Product Usage Information

This product is intended for research use only (RUO). Optimal dilutions/concentrations should be determined by the end user.

Formulation

Supplied in 1X PBS, BSA and Azide Free.

Storage

Store at -20°C. This product will freeze at -20°C so it is recommended to aliquot into single-use vials to avoid multiple freeze/thaw cycles. A slight precipitate may be present and can be dissolved by gently vortexing. This will not interfere with antibody performance.

Specificity / Sensitivity

APP (Aducanumab Biosimilar) Human mAb was confirmed to bind to its intended target aggregated Aβ using bio-layer interferometry.

Species Reactivity:

Human

Source / Purification

APP (Aducanumab Biosimilar) Human mAb is produced at Cell Signaling Technology. Aducanumab is an antibody directed against aggregated Aβ.

Background

Amyloid β (Aβ) precursor protein (APP) is a 100-140 kDa transmembrane glycoprotein that exists as several isoforms (1). The amino acid sequence of APP contains the amyloid domain, which can be released by a two-step proteolytic cleavage (1). The extracellular deposition and accumulation of the released Aβ fragments form the main components of amyloid plaques in Alzheimer's disease (1). APP can be phosphorylated at several sites, which may affect the proteolytic processing and secretion of this protein (2-5). Phosphorylation at Thr668 (a position corresponding to the APP695 isoform) by cyclin-dependent kinase is cell-cycle dependent and peaks during G2/M phase (4). APP phosphorylated at Thr668 exists in adult rat brain and correlates with cultured neuronal differentiation (5,6).

Database Links

UniProt ID: P05067

Entrez-Gene Id: 351

Limited Uses

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For Research Use Only. Not For Use In Diagnostic Procedures.

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