Atg2A Antibody #15011
- WB
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 213 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Atg2 proteins also function in lipid droplet metabolism as depletion of both Atg2A and AtgB results in changes in the size, number, and distribution of lipid droplets (7,8). These morphological changes in lipid droplets are not observed in Atg5-depleted cells, suggesting that this function is independent of the role of Atg2 in autophagy (7). Starvation-induced autophagy directs Atg2A (along with Atg14L) to localize to early autophagosomal membranes enriched in PI3P, while another subpopulation of Atg2A and Atg14L localizes to the lipid droplets independent of autophagic status (8). An increase in Atg2A expression during etoposide- and doxorubicin-induced apoptosis suggests that Atg2A may be a useful indicator of topoisomerase II inhibitor-mediated apoptosis (9). Mutations in the corresponding Atg2B gene are associated with gastric and colorectal carcinomas with high microsatellite instability (10).
- Reggiori, F. and Klionsky, D.J. (2002) Eukaryot Cell 1, 11-21.
- Shintani, T. et al. (2001) J Biol Chem 276, 30452-60.
- Wang, C.W. et al. (2001) J Biol Chem 276, 30442-51.
- Suzuki, K. et al. (2001) EMBO J 20, 5971-81.
- Obara, K. et al. (2008) J Biol Chem 283, 23972-80.
- Reggiori, F. et al. (2004) Dev Cell 6, 79-90.
- Velikkakath, A.K. et al. (2012) Mol Biol Cell 23, 896-909.
- Pfisterer, S.G. et al. (2014) J Lipid Res 55, 1267-78.
- Kusama, Y. et al. (2009) Apoptosis 14, 1165-75.
- Kang, M.R. et al. (2009) J Pathol 217, 702-6.
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