β-Amyloid (1-43) (E8C2D) Rabbit mAb #32098
- WB
- IF
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 6 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IF-Immunofluorescence
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunofluorescence (Frozen) | 1:200 - 1:800 |
Storage
For a carrier free (BSA and azide free) version of this product see product #29691.
Protocol
Specificity / Sensitivity
Species Reactivity:
The antigen sequence used to produce this antibody shares 100% sequence homology with the species listed here, but reactivity has not been tested or confirmed to work by CST. Use of this product with these species is not covered under our Product Performance Guarantee.
Species predicted to react based on 100% sequence homology:
Source / Purification
Background
Aβ43 has been suggested as a biomarker in early onset of Alzheimer's disease, where patients have lower levels of Aβ43 in cerebrospinal fluid (7,8,9). Several studies have shown that Aβ toxicity of Aβ43 is as high as Aβ42 or Aβ40 in different models of Alzheimer's disease, including mouse models and human disease. (10).
- Selkoe, D.J. (1996) J Biol Chem 271, 18295-8.
- Caporaso, G.L. et al. (1992) Proc Natl Acad Sci USA 89, 3055-9.
- Hung, A.Y. and Selkoe, D.J. (1994) EMBO J 13, 534-42.
- Suzuki, T. et al. (1994) EMBO J 13, 1114-22.
- Ando, K. et al. (1999) J Neurosci 19, 4421-7.
- Iijima, K. et al. (2000) J Neurochem 75, 1085-91.
- Lauridsen, C. et al. (2017) Front Aging Neurosci 9, 210.
- Almdahl, I.S. et al. (2017) Front Aging Neurosci 9, 9.
- Pachahara, S.K. et al. (2015) PLoS One 10, e0136567.
- Trambauer, J. et al. (2017) Methods Enzymol 584, 157-183.
Limited Uses
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