BACE2 (E3Y9Q) Rabbit mAb #80357
- WB
- IF
Supporting Data
| REACTIVITY | H M |
| SENSITIVITY | Endogenous |
| MW (kDa) | 57 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IF-Immunofluorescence
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunofluorescence (Frozen) | 1:400 - 1:1600 |
| Immunofluorescence (Immunocytochemistry) | 1:800 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
BACE2 expression in the brain is lower, both in comparison to that of BACE and to its expression level in the periphery. However, expression of BACE2 within the brain has been seen to increase during aging and in the context of neurodegenerative disease, further supporting the role it may play in disease progression (5,6). BACE2 may also play a role in disease progression in the periphery. For instance, in the pancreas, BACE2 has been implicated in regulating β-cell function and mass in the context of type II diabetes (2,7).
- Yan, R. (2017) Front Mol Neurosci 10, 97.
- Casas, S. et al. (2010) Am J Physiol Endocrinol Metab 299, E1087-95.
- Sun, X. et al. (2006) FASEB J 20, 1369-76.
- Qiu, K. et al. (2020) BMC Mol Cell Biol 21, 13.
- Wang, Z. et al. (2019) JCI Insight 4, e123431. doi: 10.1172/jci.insight.123431.
- Holler, C.J. et al. (2012) Am J Pathol 180, 337-50.
- Esterházy, D. et al. (2011) Cell Metab 14, 365-77.
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