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PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464

BACH2 Antibody #12809

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Filter:
  • WB
Western Blotting Image 1: BACH2 Antibody
Western blot analysis of extracts from RL and Daudi cells using BACH2 Antibody.
This product is discontinued

Inquiry Info. # 12809

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Supporting Data

REACTIVITY H
SENSITIVITY Endogenous
MW (kDa) 130
SOURCE Rabbit
Application Key:
  • WB-Western Blotting 
Species Cross-Reactivity Key:
  • H-Human 

Product Information

Product Usage Information

Application Dilution
Western Blotting 1:1000

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

BACH2 Antibody recognizes endogenous levels of total BACH2 protein.

Species Reactivity:

Human

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala304 of human BACH2 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Background

The transcription regulator BTB and CNC homolog 2 (BACH2) is a bZIP domain-containing transcriptional repressor that dimerizes with MafK and binds Maf recognition elements (MAREs) to regulate transcription (1,2). BACH2 is part of a network of transcription factors that controls the transition of activated B cells into either antibody-producing plasma cells or memory B cells (3-5). Plasma cell differentiation requires the transcription factor Blimp1 (6). BACH2 suppresses expression of Blimp1 in activated B cells, which delays plasma cell differentiation and allows time for class switch recombination and somatic hypermutation (3-5). Genome-wide association studies have linked the genetic locus containing BACH2 to several immune-related disorders, including type 1 diabetes, celiac disease, Crohn’s disease, and the skin condition known as vitiligo (7-10).
For Research Use Only. Not For Use In Diagnostic Procedures.
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