BMP6 (Precursor Specific) (D2V5Z) Rabbit mAb #70583
- WB
- IP
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 55-65 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
BMP6 plays a critical role in iron metabolism, ovulation, and aldosterone production (5-7). Recent studies have shown that hypermethylation of the BMP6 gene promoter decreases its expression in several cancer types, which contributes to tumor growth and progression (8-11).
- Wang, E.A. et al. (1988) Proc Natl Acad Sci USA 85, 9484-8.
- Wozney, J.M. et al. (1988) Science 242, 1528-34.
- Kawabata, M. et al. (1998) Cytokine Growth Factor Rev 9, 49-61.
- Nohe, A. et al. (2004) Cell Signal 16, 291-9.
- Roth, M.P. and Coppin, H. (2009) Med Sci (Paris) 25, 678-80.
- Inagaki, K. et al. (2006) Endocrinology 147, 2681-9.
- Akiyama, I. et al. (2014) Reprod Sci 21, 772-7.
- Hashida, Y. et al. (2012) Oncol Rep 27, 825-30.
- Liu, G. et al. (2014) Oncol Rep 32, 581-8.
- He, Y. et al. (2014) PLoS One 9, e87994.
- Sangplod, P. et al. (2014) Asian Pac J Cancer Prev 15, 7091-5.
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