BRD9 (E4Q3F) Rabbit mAb #48306
- IF
- F
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | |
| Source/Isotype | Rabbit IgG |
Application Key:
- IF-Immunofluorescence
- F-Flow Cytometry
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Immunofluorescence (Immunocytochemistry) | 1:12800 - 1:25600 |
| Flow Cytometry (Fixed/Permeabilized) | 1:3200 - 1:12800 |
Storage
For a carrier free (BSA and azide free) version of this product see product #83511.
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
GLTSCR1 and its paralog GLTSCR1L along with BRD9 have been identified as unique subunits of the non-canonical BAF (ncBAF) or GBAF complex. This complex contains either GLTSCR1 or GLTSCR1L instead of an ARID subunit, while also lacking the BAF45, BAF47, and BAF57 subunits. GBAF maps to regions distinct from the PBAF and canonical BAF complexes and has also been shown to be a synthetic lethal target for BAF driven cancers such as synovial sarcomas and rhabdoid tumors (10-12).
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- Wolf, I.M. et al. (2008) J Cell Biochem 104, 1580-6.
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- Alpsoy, A. and Dykhuizen, E.C. (2018) J Biol Chem 293, 3892-903.
- Mashtalir, N. et al. (2018) Cell 175, 1272-1288.e20.
- Michel, B.C. et al. (2018) Nat Cell Biol 20, 1410-20.
Limited Uses
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