C1R (E3R7T) Rabbit mAb #55653
- WB
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 95,55 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
C1R (E3R7T) Rabbit mAb recognizes endogenous levels of total C1R protein. This antibody reacts with C1R proenzyme and C1R A (heavy) chain proteins.
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human C1R protein.
Background
Complement C1R subcomponent (C1R) is a secreted serine protease module of the C1 macromolecular complex, which is a central node in complement activation via the classical pathway. Each C1 complex is stabilized by divalent calcium cations and contains, in part, a non-covalent dimer of identical C1R monomers that interact with the C1Q component of the C1 macromolecular complex (1). Each C1R monomer is synthesized as a proenzyme and is auto-activated within the C1 complex upon recognition of antigen-antibody complexes by C1Q (2,3). Activation of C1R leads to its cleavage into a disulfide-linked amino-terminal A (heavy) chain and a carboxyl terminal B (light) chain. The B chain contains serine protease activity that triggers a cascade of downstream enzymatic reactions that govern the classical pathway of complement (4,5).
Limited Uses
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