CA2 Antibody #8612
- WB
- IP
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 28 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
CA2 is a cytosolic member of the α class. It is the most widely distributed isoform among the mammalian CAs (1). Defects in CA2 are associated with osteopetrosis and renal tubular acidosis (3-5). Elevated expression of CA2 is observed in patients with Alzheimer’s disease and the developing brains of Down syndrome patients (6,7). CA2 is also overexpressed in Gastrointestinal Stromal Tumors (GISTs) and is considered a useful marker for diagnosis (8). Recently, CA2 was reported to facilitate transporter activity of the monocarboxylate transporter isoform 1 and 4 (MCT1/4) independent of its own catalytic activity (9,10)
- Smith, K.S. et al. (1999) Proc Natl Acad Sci USA 96, 15184-9.
- Tripp, B.C. et al. (2001) J Biol Chem 276, 48615-8.
- McMahon, C. et al. (2001) Blood 97, 1947-50.
- Borthwick, K.J. et al. (2003) J Med Genet 40, 115-21.
- Lai, L.W. et al. (1998) J Clin Invest 101, 1320-5.
- Palminiello, S. et al. (2008) Brain Res 1190, 193-205.
- Jang, B.G. et al. (2010) J Alzheimers Dis 21, 939-45.
- Parkkila, S. et al. (2010) Mod Pathol 23, 743-50.
- Becker, H.M. et al. (2005) J Biol Chem 280, 39882-9.
- Becker, H.M. et al. (2011) Proc Natl Acad Sci USA 108, 3071-6.
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