CADM4/IgSF4C (E2Y4D) Rabbit mAb #57677
- WB
Supporting Data
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 60 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
CADM4/IgSF4C (E2Y4D) Rabbit mAb recognizes endogenous levels of total CADM4/IgSF4C protein.
Species Reactivity:
Human, Mouse, Rat
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala372 of mouse CADM4/IgSF4C protein.
Background
Cell adhesion molecule 4 (CADM4), also known as immunoglobulin superfamily member 4C (IgSF4C), is an oligodendrocyte-enriched membrane protein. CADM4/IgSF4C is also a member of the cell adhesion molecules (CAMs) family. CAMs are cell membrane glycoproteins that function in cell-cell or cell-matrix interactions. The biological function of CAMs is broad and diverse (1). In the brain, CAMs play a critical role in establishing and maintaining proper neuronal structures and function by mediating extracellular interactions between cells (2). CADM4/IgSF4C is a member of a small group of CAMs (CADM1-CADM4) (3). CADM1-CADM4, also known as synaptic adhesion molecules (SynCam) and nectin-like adhesion molecules (Necl), are characterized by three immunoglobulin-like domains contained in their extracellular region. CADM1-CADM4 likely play an important role in proper myelination of neuronal axons, which is required for proper interneuronal communication, by mediating contact between axons and oligodendrocytes. Altering CADM4 function in oligodendrocytes results in hypomyelination and myelin abnormalities, consistent with the proposed function of these proteins in establishing and maintaining axonal myelination (4).
Limited Uses
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