Render Target: STATIC
Render Timestamp: 2024-11-25T10:40:27.727Z
Commit: 5c4accf06eb7154018ba3f54329c7590f97f534a
XML generation date: 2024-09-30 01:58:31.155
Product last modified at: 2024-10-31T20:45:10.442Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

CAPZA1 (E3U1G) Rabbit mAb #62114

Filter:
  • WB

    Supporting Data

    REACTIVITY H M R
    SENSITIVITY Endogenous
    MW (kDa) 33
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    CAPZA1 (E3U1G) Rabbit mAb recognizes endogenous levels of total CAPZA1 protein. This antibody does not cross-react with CAPZA2 protein. Based on the sequence of the peptide antigen, this antibody is not expected to cross-react with CAPZA3 protein.

    Species Reactivity:

    Human, Mouse, Rat

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Arg86 of human CAPZA1 protein.

    Background

    The F-actin-capping protein, a ubiquitously expressed heterodimer composed of structurally similar α and β subunits, regulates cytoskeletal organization and function by binding to the actin filament barbed ends and maintaining the cellular pool of monomeric actin (1).

    F-actin-capping protein subunit α-1 (CAPZA1) overexpression is linked to more favorable prognosis in gastric cancer (2). In hepatocellular carcinoma, CAPZA1 inhibits epithelial-mesenchymal transition (EMT), migration, and invasion (3,4).  
    For Research Use Only. Not For Use In Diagnostic Procedures.
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