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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

Cathepsin H (E6L4W) Rabbit mAb #54007

Filter:
  • WB
Western Blotting Image 1: Cathepsin H (E6L4W) Rabbit mAb
Western blot analysis of extracts from mouse kidney and brain tissues, untreated (-) or treated with peptide N-glycosidase F (PNGase F; +), using Cathepsin H (E6L4W) Rabbit mAb (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower). Negative expression of cathepsin H protein in mouse brain tissue is consistent with the predicted expression pattern.

To Purchase # 54007

Cat. # Size Qty. Price
54007T 20 µl
$168
54007S 100 µl
$371

Supporting Data

REACTIVITY H M R
SENSITIVITY Endogenous
MW (kDa) 25
Source/Isotype Rabbit IgG
Application Key:
  • WB-Western Blotting 
Species Cross-Reactivity Key:
  • H-Human 
  • M-Mouse 
  • R-Rat 
  • Related Products

Product Information

Product Usage Information

Application Dilution
Western Blotting 1:1000

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

Cathepsin H (E6L4W) Rabbit mAb recognizes endogenous levels of mature cathepsin H protein.

Species Reactivity:

Human, Mouse, Rat

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly309 of mouse cathepsin H protein.

Background

Cathepsin H (CTSH) is a broadly expressed lysosomal cysteine protease involved in the normal degradation of proteins. CTSH is synthesized as an inactive proenzyme that contains a prodomain and a mature domain, whereupon prodomain removal, the enzyme becomes active (1). High expression of CTSH is found in several cancer types, including thyroid carcinoma (2). CTSH can also process specific proteins, like the cytoskeletal protein talin, to regulate cellular processes, such as the abnormal migration of prostate cancer cells (3). The human gene encoding CSTH is also genetically linked to Alzheimer’s disease (4).
For Research Use Only. Not For Use In Diagnostic Procedures.
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