Cavin-1 (D8C1D) Rabbit mAb #46379
- WB
- IP
- IF
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 50 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
- IF-Immunofluorescence
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
| Immunofluorescence (Immunocytochemistry) | 1:800 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
The cavin proteins (cavin-1, -2, -3, and -4 in mammals) are a family of caveolae-associated integral membrane proteins involved in the biogenesis and stability of caveolae. Cavin proteins form homo- or hetero-oligomers whose composition is tissue-specific, which may confer distinct functions of caveolae in various tissues (3). Cavin-1 (PTRF), which is widely expressed, is required for caveolae formation and is thought to play roles in lipid metabolism, adipocyte differentiation, and IGF-1 receptor signaling (4-6). Research studies involving prostate cancer suggest that expression of cavin-1 is related to tumor progression and angiogenesis/lymphangiogenesis (7-8).
- Bastiani, M. and Parton, R.G. (2010) J Cell Sci 123, 3831-6.
- Cohen, A.W. et al. (2004) Physiol Rev 84, 1341-79.
- Kovtun, O. et al. (2015) J Cell Sci 128, 1269-78.
- Ding, S.Y. et al. (2014) J Biol Chem 289, 8473-83.
- Perez-Diaz, S. et al. (2014) FASEB J 28, 3769-79.
- Hamoudane, M. et al. (2013) J Endocrinol Invest 36, 204-8.
- Nassar, Z.D. et al. (2013) Nat Rev Urol 10, 529-36.
- Nassar, Z.D. et al. (2013) Oncotarget 4, 1844-55.
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