CCDC124 (E2G4Q) Rabbit mAb #79516

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Supporting Data

REACTIVITY	H M R Mk
SENSITIVITY	Endogenous
MW (kDa)	28
Source/Isotype	Rabbit IgG

Application Key:

WB-Western Blotting
IP-Immunoprecipitation

Species Cross-Reactivity Key:

H-Human
M-Mouse
R-Rat
Mk-Monkey

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000
Immunoprecipitation	1:50

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

CCDC124 (E2G4Q) Rabbit mAb recognizes endogenous levels of total CCDC124 protein.

Species Reactivity:

Human, Mouse, Rat, Monkey

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human CCDC124 protein.

Background

Translation is reversibly shut down in cells that are deprived of nutrients. In these cells, ribosomes bind to inhibitory factors and are kept inactive. After nutrient deprivation, translation recovers. CCDC124 (coiled-coil domain-containing protein 124/coiled-coil domain-containing short open reading frame 124) plays an active role in translation recovery after starvation (1). In addition, research studies show that the non-structural protein 1 (Nsp1) from SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2) associates with ribosomes and shuts down host protein translation. CCDC124 is in one of the two major populations of translationally inactive ribosomes in the Nsp1-bound 80S complexes (2).

Database Links

UniProt ID: Q96CT7

Entrez-Gene Id: 115098

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For Research Use Only. Not For Use In Diagnostic Procedures.

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