Name: CCL18 (F9S6V) Rabbit mAb
Price: 364.00 USD
Availability: InStock

Filter:

WB
F

Supporting Data

REACTIVITY	H
SENSITIVITY	Endogenous
MW (kDa)	9
Source/Isotype	Rabbit IgG

Application Key:

WB-Western Blotting
F-Flow Cytometry

Species Cross-Reactivity Key:

H-Human

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000
Flow Cytometry (Fixed/Permeabilized)	1:200 - 1:800

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

CCL18 (F9S6V) Rabbit mAb recognizes endogenous levels of total CCL18 protein. This antibody does not cross-react with CCL3/MIP-1α or CCL4 proteins.

Species Reactivity:

Human

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human CCL18 protein.

Background

C-C motif chemokine ligand 18 (CCL18, PARC, MIP-4, AMAC-1, DC-CK1) is a member of the CC chemokine family involved in signaling and coordinating immune responses (1-3). CCL18 is a secreted protein, primarily expressed by macrophages, monocytes, and dendritic cells (1-3). Th2-associated anti-inflammatory cytokines such as IL-4, IL-13, and IL-10 can polarize macrophages into an M2 phenotype, which induces CCL18 expression (3,4). In cancer, tumor-associated macrophages (TAMs) may secrete large amounts of CCL18, causing an immunosuppressive tumor microenvironment, which can lead to cancer immune evasion (5).

Database Links

UniProt ID: P55774

Entrez-Gene Id: 6362

Limited Uses

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Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.

For Research Use Only. Not For Use In Diagnostic Procedures.

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CCL18 (F9S6V) Rabbit mAb #23957