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Inquiry Info. # 3565

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Supporting Data

REACTIVITY	H
SENSITIVITY	Endogenous
MW (kDa)	100
Source/Isotype	Mouse IgG1

Application Key:

F-Flow Cytometry

Species Cross-Reactivity Key:

H-Human

Product Information

Product Usage Information

Application	Dilution
Flow Cytometry (Fixed/Permeabilized)	1:25

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

CD10 (CB-CALLA) Mouse mAb detects endogenous levels of CD10.

Species Reactivity:

Human

Source / Purification

Monoclonal antibody is produced by immunizing BALB/c mice with CALLA cells.

Background

CD10 (CALLA or neprilysin) was identified as a marker for leukemic cells in children with acute lymphoblastic leukemia and belongs to a family of exoenzymes that include aminopeptidase A, N and dipeptidylpeptidase IV (1-2). CD10 is a transmembrane type II molecule and functions as a metallo-peptidase requiring zinc. Specifically, CD10 cleaves 1-3 amino-terminal amino acids from peptides with a preference for neutral amino acids (valine, iso-leucine, phenylalanine, leucine or alanine) (2). The CD10 antigen is expressed by immature and by germinal center B cells, by granulocytes and by acute B-cell lymphoblastic leukemia cells. Therefore, CD10 appears to be involved in late stage regulation of hematopoietic cells (3).

Database Links

UniProt ID: P08473

Entrez-Gene Id: 4311

Limited Uses

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For Research Use Only. Not For Use In Diagnostic Procedures.

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CD10 (CB-CALLA) Mouse mAb #3565