CD20 (Rituximab Biosimilar) Human mAb #91213

Supporting Data

REACTIVITY	H
SENSITIVITY	Endogenous
MW (kDa)
Source/Isotype	Human IgG1 kappa

Species Cross-Reactivity Key:

H-Human

Product Information

Product Description

CD20 (Rituximab Biosimilar) Human mAb is a biosimilar antibody for Rituximab. Rituximab is a therapeutic human monoclonal antibody directed against CD20 which is expressed on various B cell cancers such as some forms of B cell non-Hodgkin lymphoma, chronic lymphocytic leukemia, and B cell acute leukemia.

Endotoxin

<0.1 EU/μg of antibody

Product Usage Information

This product is intended for research use only (RUO). Optimal dilutions/concentrations should be determined by the end user.

Formulation

Supplied in 1X PBS, BSA and Azide Free.

Storage

Store at -20°C. This product will freeze at -20°C so it is recommended to aliquot into single-use vials to avoid multiple freeze/thaw cycles. A slight precipitate may be present and can be dissolved by gently vortexing. This will not interfere with antibody performance.

Specificity / Sensitivity

CD20 (Rituximab Biosimilar) Human mAb was confirmed to bind to its intended target protein CD20 using flow cytometry.

Species Reactivity:

Human

Source / Purification

CD20 (Rituximab Biosimilar) Human mAb is produced at Cell Signaling Technology. Rituximab is an antibody directed against the extracellular region of human CD20.

Background

B-lymphocyte antigen CD20 (also known as MS4A1; Membrane-spanning 4-domains subfamily A member 1) is a cell surface phosphoprotein involved in the regulation of B cell activation and proliferation (1,2). It is commonly used as a marker to identify B cells and is expressed throughout B cell development, up until their differentiation into plasma cells. CD20 has no known ligand, and its expression and function are largely conserved between human and mouse (1-3). Evidence suggests that CD20 is necessary for store operated calcium (SOC) entry, which leads to elevated cytoplasmic calcium levels required for B cell activation (4,5). Anti-CD20 antibody immunotherapy depletes B cells by activation of the innate monocytic network and is a common treatment for B cell lymphomas, leukemias, and autoimmune diseases (6).

Database Links

UniProt ID: P11836

Entrez-Gene Id: 931

Limited Uses

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For Research Use Only. Not For Use In Diagnostic Procedures.

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