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Commit: c91f970ca8df4f527662a05c7bd6e4d03c6fa173
XML generation date: 2025-03-07 13:14:40.766
Product last modified at: 2025-03-13T11:45:16.571Z
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PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464

CD70 Antibody #72094

Filter:
  • WB
Western Blotting Image 1: CD70 Antibody
Western blot analysis of extracts from various cell lines using CD70 Antibody (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower).

To Purchase # 72094

Cat. # Size Qty. Price
72094S 100 µl
$392

Supporting Data

REACTIVITY H
SENSITIVITY Endogenous
MW (kDa) 25-30
SOURCE Rabbit
Application Key:
  • WB-Western Blotting 
Species Cross-Reactivity Key:
  • H-Human 
  • Related Products

Product Information

Product Usage Information

Application Dilution
Western Blotting 1:1000

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

CD70 Antibody recognizes endogenous levels of total CD70 protein.

Species Reactivity:

Human

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly187 of human CD70 protein. Antibodies are purified by peptide affinity chromatography.

Background

CD70 is a type II transmembrane glycoprotein and a member of the tumor necrosis factor ligand superfamily (TNFSF), also known as CD27L and TNFSF7. It is normally expressed on medullary thymic epithelial cells. Its expression is induced on activated lymphoid cells (B cells, T cells, and NK cells) and dendritic cells. CD70 is a ligand for CD27, a co-stimulatory receptor that plays an important role in T cell activation and proliferation (1,2). CD70 overexpression has been reported in various tumors such as renal cell carcinoma, glioblastoma, and non-small cell lung carcinoma and it’s being actively pursued as a therapeutic target (3-6).
For Research Use Only. Not For Use In Diagnostic Procedures.
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