Render Target: STATIC
Render Timestamp: 2024-11-14T10:43:28.995Z
Commit: 3c1f305a63297e594ac8d7bb5424007d592d68be
XML generation date: 2024-08-01 15:28:21.342
Product last modified at: 2024-06-27T13:37:01.432Z
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PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464

CD84 Antibody #41033

Filter:
  • WB
  • IP

    Supporting Data

    REACTIVITY M
    SENSITIVITY Endogenous
    MW (kDa) 45-80
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • M-Mouse 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:100

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    CD84 Antibody recognizes endogenous levels of total CD84 protein. This antibody cross-reacts with an unidentified protein of 17 kDa.

    Species Reactivity:

    Mouse

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala322 of mouse CD84 protein. Antibodies are purified by peptide affinity chromatography.

    Background

    Cluster of Differentiation 84 (CD84), also known as signaling lymphocytic activation molecule family member 5 (SLAMF5), is a membrane glycoprotein expressed by numerous immune cell types, including hematopoietic progenitor cells, T cells, B cells, NK cells, macrophages, monocytes, dendritic cells, platelets, mast cells, and thymocytes (1-9). CD84 is a homophilic adhesion molecule involved in modulating the activation, differentiation, proliferation, and cytotoxicity of a wide variety of immune cells, and thus is involved in the regulation and interconnection of both the innate and adaptive immune response (6-14). Certain CD84 activities are regulated by the presence or absence of small cytoplasmic adaptor proteins, SH2D1A/SAP and/or SH2D1B/EAT-2 (5,14). Alternate splicing results in multiple transcript variants.
    For Research Use Only. Not For Use In Diagnostic Procedures.
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