Render Target: STATIC
Render Timestamp: 2024-11-20T11:39:01.159Z
Commit: 5c4accf06eb7154018ba3f54329c7590f97f534a
XML generation date: 2024-09-30 01:57:35.864
Product last modified at: 2024-09-30T08:00:19.777Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

CDC40 (E4V4J) Rabbit mAb #99086

Filter:
  • WB
  • IP
  • eCLIP

    Supporting Data

    REACTIVITY H M R
    SENSITIVITY Endogenous
    MW (kDa) 75
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    • eCLIP-eCLIP 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:50
    eCLIP 1:200
    For more information about the RBP-eCLIP service please visit Eclipsebio.

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    CDC40 (E4V4J) Rabbit mAb recognizes endogenous levels of total CDC40 protein.

    Species Reactivity:

    Human, Mouse, Rat

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro459 of human CDC40 protein.

    Background

    CDC40/ PRP17 (Pre-mRNA-processing factor 17) is associated with the activated spliceosome, and is required for pre-mRNA splicing. CDC40 is necessary for efficient G1/S and G2/M transitions, linking splicing to control of cell cycle progression (1,2).CDC40 expression is induced in hepatitis B virus (HBV)-infected hepatocellular carcinoma (HCC) cells through NF-κB and miR-1269b, promoting malignancy in HCC (3).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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