CDC40 (E4V4J) Rabbit mAb #99086
- WB
- IP
- eCLIP
Supporting Data
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 75 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
- eCLIP-eCLIP
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
| eCLIP | 1:200 |
Storage
Protocol
Specificity / Sensitivity
CDC40 (E4V4J) Rabbit mAb recognizes endogenous levels of total CDC40 protein.
Species Reactivity:
Human, Mouse, Rat
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro459 of human CDC40 protein.
Background
CDC40/ PRP17 (Pre-mRNA-processing factor 17) is associated with the activated spliceosome, and is required for pre-mRNA splicing. CDC40 is necessary for efficient G1/S and G2/M transitions, linking splicing to control of cell cycle progression (1,2).CDC40 expression is induced in hepatitis B virus (HBV)-infected hepatocellular carcinoma (HCC) cells through NF-κB and miR-1269b, promoting malignancy in HCC (3).
Limited Uses
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