CDIP Antibody #13824
- WB
- IP
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 24,26 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
Storage
Protocol
Specificity / Sensitivity
CDIP Antibody recognizes endogenous levels of total CDIP protein. This antibody may detect proteins of unknown origin at 35 and 70 kDa in some cell lines.
Species Reactivity:
Human
The antigen sequence used to produce this antibody shares 100% sequence homology with the species listed here, but reactivity has not been tested or confirmed to work by CST. Use of this product with these species is not covered under our Product Performance Guarantee.
Species predicted to react based on 100% sequence homology:
Mouse, Rat
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human CDIP protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background
Cell Death Involved p53-Target (CDIP) is a pro-apoptotic protein induced by genotoxic stress in a p53-dependent manner (1). Indeed, CDIP is a direct target of p53. Inhibition of CDIP impairs p53-mediated apoptosis. Induction of apoptosis by CDIP requires caspase-8 suggesting involvement in the extrinsic apoptotic pathway. CDIP also promotes increased expression of TNF-α capable of triggering apoptosis. Furthermore, expression of CDIP correlates with increased sensitivity of TNF-α-induced apoptosis (2). These studies suggest that CDIP may serve as a marker for apoptotic sensitivity.
Limited Uses
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