CDK10 (D8Z7Z) Rabbit mAb #36106
- WB
Supporting Data
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 40 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
CDK10 is activated by cyclin M, which is mutated and unable to activate CDK10 in the human developmental disorder, STAR syndrome. Phosphorylation of Ets2 by CDK10/Cyclin M leads to degradation of Ets2 by the proteasome (2). CDK10 also plays a role in the development of the zebrafish nervous system (3). Studies have shown that expression of CDK10, which is modulated by promoter hypermethylation, is decreased in human cancer (4-6). Further, studies show that CDK10 expression in breast cancer affects response to tamoxifen (7), and is correlated with disease progression (8). CDK10 regulates the expression of c-RAF, and signaling through the MAPK pathway (2-3, 6-7).
- Kasten, M. and Giordano, A. (2001) Oncogene 20, 1832-8.
- Guen, V.J. et al. (2013) Proc Natl Acad Sci U S A 110, 19525-30.
- Yeh, C.W. et al. (2013) J Biol Chem 288, 27927-39.
- You, Y. et al. (2013) Cell Oncol (Dordr) 36, 323-31.
- Zhong, X.Y. et al. (2012) Gene 498, 68-74.
- Yu, J.H. et al. (2012) Oncol Rep 27, 1266-76.
- Iorns, E. et al. (2008) Cancer Cell 13, 91-104.
- You, Y. et al. (2015) Cell Oncol (Dordr) 38, 485-91.
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