CEACAM7 (E5Q6X) Rabbit mAb (BSA and Azide Free) #34209
- WB
- IHC
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 55 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IHC-Immunohistochemistry
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
This formulation is ideal for use with technologies requiring specialized or custom antibody labeling, including fluorophores, metals, lanthanides, and oligonucleotides. It is not recommended for ChIP, ChIP-seq, CUT&RUN or CUT&Tag assays. If you require a carrier free formulation for chromatin profiling, please contact us. Optimal dilutions/concentrations should be determined by the end user.
Formulation
Storage
Specificity / Sensitivity
CEACAM7 (E5Q6X) Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of total CEACAM7 protein.
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val141 of human CEACAM7 protein.
Background
Carcinoembryonic antigen (CEA)-related cell adhesion molecule 7 (CEACAM7) is a homodomeric glycoprotein that is covalently linked to the plasma membrane via a GPI anchor and modulates cell adhesion via its N-terminal IgV domain (1). In normal human tissues, CEACAM7 expression is largely restricted to epithelial cells of the colon and pancreatic ducts (2). While some research studies have demonstrated that CEACAM7 expression is downregulated in human colorectal carcinomas, other studies have highlighted high expression levels in some pancreatic ductal adenocarcinomas (PDAC) (3-5). Given the restricted expression pattern in normal human tissues, CEACAM7 is positioned as an attractive immunotherapeutic target for PDAC (4).
- Bonsor, D.A. et al. (2015) Acta Crystallogr F Struct Biol Commun 71, 1169-75.
- Schölzel, S. et al. (2000) Am J Pathol 156, 595-605.
- Thompson, J. et al. (1994) J Biol Chem 269, 32924-31.
- Raj, D. et al. (2021) Clin Cancer Res 27, 1538-1552.
- Dhasmana, A. et al. (2023) J Adv Res, 00064-4. doi: 10.1016/j.jare.2023.02.013.
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