Choline Kinase α (D5X9W) Rabbit mAb #13422
- WB
- IP
Supporting Data
| REACTIVITY | H Mk |
| SENSITIVITY | Endogenous |
| MW (kDa) | 50 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
- Mk-Monkey
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:100 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Research studies indicate that ChoKα levels affect signaling through MAPK and Akt pathways (2,3). Investigators have shown that ChoKα plays a role in proliferation and carcinogenesis and is highly expressed/activated in human cancers (4-7). Additional research studies suggest ChoKα may be a potential target for cancer therapy (8).
- Janardhan, S. et al. (2006) Curr Med Chem 13, 1169-86.
- Yalcin, A. et al. (2010) Oncogene 29, 139-49.
- Chua, B.T. et al. (2009) Mol Cancer 8, 131.
- Ramírez de Molina, A. et al. (2002) Oncogene 21, 4317-22.
- Ramírez de Molina, A. et al. (2007) Lancet Oncol 8, 889-97.
- Hernando, E. et al. (2009) Oncogene 28, 2425-35.
- Miyake, T. and Parsons, S.J. (2012) Oncogene 31, 1431-41.
- Bañez-Coronel, M. et al. (2008) Curr Cancer Drug Targets 8, 709-19.
Limited Uses
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