Cleaved TGF-β1 (Ala279)/ TGF-β2 (Ala303)/ TGF-β3 (Ala301) Antibody #84912
- WB
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 12 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
There are three TGF-β family members, designated TGF-β1, TGF-β2, and TGF-β3, which are encoded by distinct genes and are expressed in a tissue-specific manner (10). TGF-β proteins are synthesized as precursor proteins that are cleaved and reassembled in association with other proteins to form latent complexes. Activation occurs by proteolytic release of TGF-β monomers, which dimerize to form the mature TGF-β ligands.
- Massagué, J. et al. (2000) Cell 103, 295-309.
- de Caestecker, M.P. et al. (2000) J Natl Cancer Inst 92, 1388-402.
- Derynck, R. et al. (2001) Nat Genet 29, 117-29.
- Derynck, R. and Feng, X.H. (1997) Biochim Biophys Acta 1333, F105-50.
- Miyazono, K. et al. (2000) Adv Immunol 75, 115-57.
- Massagué, J. (2000) Nat Rev Mol Cell Biol 1, 169-78.
- Derynck, R. et al. (1998) Cell 95, 737-40.
- López-Casillas, F. et al. (1991) Cell 67, 785-95.
- Kingsley, D.M. (1994) Genes Dev 8, 133-46.
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