Render Target: STATIC
Render Timestamp: 2024-11-21T13:25:22.591Z
Commit: 5c4accf06eb7154018ba3f54329c7590f97f534a
XML generation date: 2024-09-30 01:58:23.220
Product last modified at: 2024-09-30T08:01:07.454Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

COL14A1 (E5W8S) Rabbit mAb #61964

Filter:
  • WB
  • IHC

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 220
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IHC-Immunohistochemistry 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunohistochemistry (Paraffin) 1:50 - 1:200

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    For a carrier free (BSA and azide free) version of this product see product #58865.

    Protocol

    Specificity / Sensitivity

    COL14A1 (E5W8S) Rabbit mAb recognizes endogenous levels of total COL14A1 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human COL14A1 protein.

    Background

    COL14A1 (Collagen Type XIV, Undulin) is an interstitial collagen that belongs to the fibril-associated collagens with interrupted triple helices (FACIT) family (1). COL14A1 contributes to the assembly and remodeling of the interstitial extracellular matrix, in part by promoting the formation of inter-molecular bridges between collagen molecules (2-4). Changes in COL14A1 expression have been identified as a potential biomarker in a variety of fibrotic diseases, including idiopathic pulmonary fibrosis (5,6) and fibrotic kidney diseases (7). A study of tumor stroma-associated biomarkers furthermore revealed that COL14A1 was one of a group of genes whose expression correlated negatively with clinical stage of breast cancer patient samples (8).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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