Contactin-2 (D4M7G) Rabbit mAb #26372
- WB
Supporting Data
| REACTIVITY | M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 130 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
The antigen sequence used to produce this antibody shares 100% sequence homology with the species listed here, but reactivity has not been tested or confirmed to work by CST. Use of this product with these species is not covered under our Product Performance Guarantee.
Species predicted to react based on 100% sequence homology:
Source / Purification
Background
Contactin-2 (CNTN2, TAG-1) is a glycosyl-phosphatidyl-inositol-anchored cell adhesion protein that is expressed at the juxtaparanodal region of the nodes of Ranvier by oligodendrocytes, Schwann cells, and axons (9,10). Contactin-2 plays an important role in the proper organization of the juxtaparanodes through interaction with Caspr2 and the recruitment of the Kv1.1 and Kv1.2 potassium channel subunits (11). Research studies indicate that contactin-2 is a substrate of β-secretase 1 (12,13). A deletion mutation in the corresponding CNTN2 gene results in familial adult myoclonic epilepsy-5, which is characterized by seizures, involuntary myoclonic muscle twitches, and mild intellectual disability (14).
- Black, J.A. et al. (1990) Trends Neurosci 13, 48-54.
- Salzer, J.L. (1997) Neuron 18, 843-6.
- Waxman, S.G. et al. (1989) Proc Natl Acad Sci U S A 86, 1406-10.
- Ritchie, J.M. (1992) Trends Neurosci 15, 345-51.
- Berghs, S. et al. (2000) J Cell Biol 151, 985-1002.
- Zhou, D. et al. (1998) J Cell Biol 143, 1295-304.
- Davis, J.Q. et al. (1996) J Cell Biol 135, 1355-67.
- Ratcliffe, C.F. et al. (2001) J Cell Biol 154, 427-34.
- Traka, M. et al. (2002) J Neurosci 22, 3016-24.
- Girault, J.A. and Peles, E. (2002) Curr Opin Neurobiol 12, 476-85.
- Traka, M. et al. (2003) J Cell Biol 162, 1161-72.
- Kuhn, P.H. et al. (2012) EMBO J 31, 3157-68.
- Gautam, V. et al. (2014) Mol Neurodegener 9, 4.
- Stogmann, E. et al. (2013) Brain 136, 1155-60.
Limited Uses
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