Cortactin Antibody #3502
- WB
- IHC
Supporting Data
| REACTIVITY | H M R Mk |
| SENSITIVITY | Endogenous |
| MW (kDa) | 80, 85 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
- IHC-Immunohistochemistry
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
- Mk-Monkey
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunohistochemistry (Paraffin) | 1:50 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Cortactin is phosphorylated at tyrosine residues 421, 466, and 482. Tyrosine phosphorylation of cortactin regulates cell motility (5), rac1-mediated actin dynamics (6), cadherin-dependent adhesion (7), chemokine trafficking and chemokine-dependent chemotaxis (8).
- Du, Y. et al. (1998) Mol Cell Biol 18, 5838-51.
- Naisbitt, S. et al. (1999) Neuron 23, 569-82.
- Rodrigo, J.P. et al. (2000) Clin Cancer Res 6, 3177-82.
- Weed, S.A. and Parsons, J.T. (2001) Oncogene 20, 6418-34.
- Huang, C. et al. (1998) J Biol Chem 273, 25770-6.
- Head, J.A. et al. (2003) Mol Biol Cell 14, 3216-29.
- El Sayegh, T.Y. et al. (2004) J Cell Sci 117, 5117-31.
- Luo, C. et al. (2006) J Biol Chem 281, 30081-93.
Limited Uses
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