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Primary Antibodies /
COX10 Antibody

COX10 Antibody #62387

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Supporting Data

REACTIVITY	H
SENSITIVITY	Endogenous
MW (kDa)	49
SOURCE	Rabbit

Application Key:

WB-Western Blotting

Species Cross-Reactivity Key:

H-Human

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

COX10 Antibody recognizes endogenous levels of total COX10 protein.

Species Reactivity:

Human

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asp31 of human COX10 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Background

COX10 is an assembly factor for cytochrome c oxidase (COX, also known as complex IV) in the mitochondrial electron transport chain (1,2). Studies show that, when the gene encoding the β2-adrenergic receptor (Adrb2) is deleted, increased oxidative phosphorylation in endothelial cells inhibits angiogenesis. Deletion of Cox10 prevents the metabolic switch to oxidative phosphorylation in endothelial cells deleted of Adrb2, causing angiogenesis and cancer progression (2). In addition, COX10 contributes to T cell quiescence exit and is critical for T cell activation (3).

Database Links

UniProt ID: Q12887

Entrez-Gene Id: 1352

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For Research Use Only. Not For Use In Diagnostic Procedures.

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