Render Target: STATIC
Render Timestamp: 2024-11-21T13:44:30.863Z
Commit: 5c4accf06eb7154018ba3f54329c7590f97f534a
XML generation date: 2024-08-01 15:28:50.764
Product last modified at: 2024-09-30T15:00:12.653Z
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PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464
  1. Products /
  2. Primary Antibodies /
  3. COX2/MT-CO2 Antibody

COX2/MT-CO2 Antibody #31219

Filter:
  • WB
  • IP

    Supporting Data

    REACTIVITY H Mk
    SENSITIVITY Endogenous
    MW (kDa) 19
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 
    • Mk-Monkey 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:50

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    COX2/MT-CO2 Antibody recognizes endogenous levels of total COX2/MT-CO2 protein. This antibody does not cross-react with COX1/MT-CO1 or COX3/MT-CO3.

    Species Reactivity:

    Human, Monkey

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro223 of human COX2/MT-CO2 protein. Antibodies are purified by peptide affinity chromatography.

    Background

    The electron transport chain (or respiratory chain) is a series of mitochondrial protein complexes (Complexes I-IV) that utilize coupled reduction-oxidation (redox) reactions to transfer electrons from donor molecules to acceptors. By coupling this electron transport with active proton pumping across the inner mitochondrial membrane, an electrochemical gradient is generated that is used to drive ATP synthesis (1). Complex IV (cytochrome c oxidase) is the terminal complex of the respiratory chain, responsible for transporting electrons from cytochrome c to molecular oxygen. COX2 (cytochrome c oxidase subunit 2), also known as MT-CO2, is one of 14 subunits of cytochrome c oxidase, and one of three subunits (COX1/MT-CO1, COX2/MT-CO2, and COX3/MT-CO3) encoded by the mitochondrial genome (2). These three mitochondrial-encoded subunits form the functional core of cytochrome c oxidase. Research studies have shown that disruptions to COX2/MT-CO2 function can have deleterious health effects. For example, a novel point mutation in the COX2/MT-CO2 gene was identified as a risk factor for cardiovascular disease (3), whereas a separate point mutation was causally linked to adult onset cerebellar ataxia (4).

    Database Links

    UniProt ID: P00403


    Entrez-Gene Id: 4513


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