Render Target: STATIC
Render Timestamp: 2024-12-20T10:57:44.080Z
Commit: f2d32940205a64f990b886d724ccee2c9935daff
XML generation date: 2024-08-01 15:28:27.769
Product last modified at: 2024-11-02T19:15:07.757Z
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PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464

CPEB4 Antibody #28748

Filter:
  • WB
  • IP

    Supporting Data

    REACTIVITY H M R Mk
    SENSITIVITY Endogenous
    MW (kDa) 90
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 
    • Mk-Monkey 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:100

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    CPEB4 Antibody recognizes endogenous levels of total CPEB4 protein.

    Species Reactivity:

    Human, Mouse, Rat, Monkey

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human CPEB4 protein. Antibodies are purified by peptide affinity chromatography.

    Background

    Cytoplasmic polyadenylation element (CPE)-binding (CPEB) proteins are a family of sequence-specific RNA-binding proteins that bind to the CPE, a uridine-rich sequence element within the mRNA 3’ UTR, to regulate mRNA translation (1). The CPEB family consists of four members in vertebrates: CPEB1, CPEB2, CPEB3, and CPEB4. All four paralogs share sequence similarities in their carboxy-terminal RNA-binding domains, but vary in the sequence of their amino-terminal regulatory domains (2). CPEB4 has specifically been linked to autism spectrum disorder (ASD), where it has been found to bind to the mRNA transcripts of most high-confidence ASD risk genes (3). Moreover, young idiopathic ASD individuals show decreased CPEB4 protein levels in the brain, and consequently decreased protein levels of multiple ASD risk gene transcripts compared to controls (3). CPEB4 is also abnormally expressed in a large number of cancers and often correlates with poor prognosis, including glioblastoma/glioma, head and neck squamous cell carcinoma, non-small cell lung cancer, colon cancer, and breast cancer, among others (4-9).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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