CRAD Antibody #39862
- WB
- IP
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 200 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
While CRAD was identified as a tumor suppressor downregulated in colorectal cancer, its expression is upregulated in other human cancers, including non-small cell lung cancer (NSCLC) and breast cancer (1-3). In NSCLC cells, downregulation of CRAD inhibits proliferation and increases the rate of apoptosis (2). Mutation of CRAD in small cell lung cancer (SCLC) may serve as a prognostic marker for overall survival (4).
Limited Uses
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